ERr 731® Siberian rhubarb extract has been clinically shown to reduce the frequency and severity of hot flashes, night sweats, heart racing, sleep disturbances, mood swings, restlessness, joint and muscle discomfort, vaginal dryness, fatigue, and irritability. A patented probiotic strain supports the gut-brain acis to improve mood and healthy cortisol levels, while grape seed extract provides stress support. Estrogen-free, non-hormonal, vegan, gluten-free, and non-GMO. Take 1 capsule at any time with food.